The opinions expressed on this website are that of my own and do not reflect that of any employer or commercial organization.
Wednesday, September 9, 2020
Tuesday, September 8, 2020
RIP-Laika
Although this really doesn't belong as an entry in my blog, in a way it does as Laika and other animals contributed to exploring and recognizing our space in the cosmos . It also refers to the title of the blog.
from WIRED :
Space Dogs uses archival footage to tell the story of the clever, docile, and doomed Moscow street dog Laika, the first mammal to go into orbit—and the first mammal to die there. In 1957, the Soviet Union sent Laika to space in the satellite Sputnik 2. Despite initial assurances to the public that the pup would come back unharmed, she was always intended as a sacrifice to scientific progress, as there was no way to return her to Earth at the time. For years, the party line from officials was that Laika had been humanely euthanized before the satellite reentered the atmosphere. In reality, she lasted less than a day before heat and stress killed her, turning the object of cosmic progress into her small coffin. The film doesn’t have footage of Laika suffering in space (thank God) but it does have plenty of clips of scientists putting Laika and a few other research dogs through a barrage of exercises—they spin in a centrifuge, dazed—and subjecting them to invasive, gruesome surgeries in order to rig them up with the necessary sensors to see how long they’d last alone above the planet’s atmosphere.
It is not a pleasant viewing experience. In fact, if I had to imagine the film I would least like to be forced to watch, Clockwork Orange-style, with my eyes pried open, it might be this one. It is a stylish and honest film—a rare combination!—but also merciless
Space Dogs from Icarus Films on Vimeo.
The ACTS Randomized Clinical Trial
Now we got three decently-sized randomized controlled trials, all in agreement: vitamin C does not reverse organ failure in sepsis," commented critical care physician Robert Dickson, MD, of the University of Michigan School of Medicine in Ann Arbor.
The VITAMINS trial showed no advantage in recovery from septic shock and numerically higher mortality with a vitamin C-hydrocortisone-thiamine combination. The CITRIS-ALI trial showed no impact on SOFA scores from high-dose IV vitamin C.
"If the signal of benefit for vitamin C was anywhere near as strong as was initially suggested, it shouldn't be this hard to detect it in clinical trials," Dickson added.
The researchers noted that vitamin C has also been proposed for treating respiratory failure from COVID-19, as was seen in a recent case report.
However, Dickson said, "the data supporting use of vitamin C in sepsis were already weak. The data supporting its use in COVID-19 are non-existent."
Any excuses Paul Marick after belittling the primary investigator of the Vitamins Trial?
Ref: Kamagurka
Featured Post
Fourth Universal Definition of Myocardial Infarction
The following are key points to remember from this Expert Consensus Document on the Fourth Universal Definition of Myocardial Infarction (M...
-
I will write more about this in the next blog, but the concept of driving pressure ( Pdr = Vt/Crs- Vt; tidal volume, Crs; compliance respir...
-
CV Medications in Pregnancy Table for Quick Review, I posted this article earlier in the year but not the Central Illustration Cardiova...
-
The following are key points to remember from this Expert Consensus Document on the Fourth Universal Definition of Myocardial Infarction (M...