Important RCT's form ESICM Vienna 10-2017

Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome Compared with conventional LTV, the early application of APRV in patients with ARDS was associated with better oxygenation and respiratory system compliance, lower plateau airway pressure, less sedation requirement, more ventilator-free days at day 28, and a shorter dura-tion of ICU stay Early goal-directed nutrition versus standard of care in adult intensivecare patients: the single-centre, randomised,outcome assessor-blinded EAT-ICU trial A single-centre, randomised, stratifed,parallel-grouped, outcome assessor-blinded clinical trial including 203 acutely admitted, adult ICU patients who were mechanically ventilated, to test the efects of a combined and individualised energy–protein nutrition guided by indirect calorimetry and 24-h urinary urea excretion (nitrogen balance), i.e. EGDN. The EGDNgroup received more energy and protein and had lower nutritional defcits in the ICU as compared to the standard of care group, but we observed no diference betweenthe two groups in physical quality of life at 6 months orin mortality, rates of organ failures, serious adverse reactions or nosocomial infections in the ICU, length of ICU or hospital stay, or days alive without life support at 90 days.