The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients

The Surviving Sepsis Guidelines suggest keeping mean arterial pressure initially above 65 mmHg, followed by individualized treatment to optimize tissue perfusion. In our analysis, risks for mortality, AKI and myocardial injury were apparent by 85  mmHg, and for mortality and AKI risk progressively worsened at lower thresholds. Until randomized trials show that the relationship between hypotension and serious complications is not causal, it would probably be prudent to keep mean arterial pressure well above 65  mmHg in septic ICU patients.


The relationship between ICUhypotension and in-hospital mortalityand morbidity in septic patients

Kamal Maheshwari1,7*, Brian H. Nathanson2 , Sibyl H. Munson3 , Victor Khangulov3 , Mitali Stevens4 , Hussain Badani3 , Ashish K. Khanna5 and Daniel I. Sessler6

Author details 1 Department of Outcomes Research, Center for Perioperative Intelligence, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA. 2 OptiStatim, LLC, Longmeadow, MA, USA. 3 Department of Health Economics and Outcomes Research, Boston Strategic Partners, Inc., Boston, MA, USA. 4 Edwards Lifesciences, Irvine, CA, USA. 5 Department of Outcomes Research, Center for Critical Care, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA. 6 Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA. 7 Department of General Anesthesiology, Anesthesiology Institute, Cleveland Clinic, 9500 Euclid Avenue, E-31, Cleveland, OH 44195, USA.