ARDS Phenotyping ( click on link for Lecture)
There isa clinical need to identify biomarkers that are associatedwith treatment response, independent of group membership. Therefore, consensus on biological sampling time
points, biological dimension measured, and a standard minimum set of consensus biomarkers is required.
The biological sampling should aim to refect the insults
to the alveolar capillary membrane (ACM) (exudative
phase), deposition of provisional matrix with proliferation of airway progenitor cells (proliferative phase), or
interstitial and intra-alveolar fbrosis (fbrotic phase) of
ARDS. Tis minimum set of markers could then be used
to delineate discriminant markers of ARDS sub-phenotypes that provide prognostic enrichment with either a
greater probability of therapeutically valid similarities or
a greater likelihood of treatment response.
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